I'm glad I found this post before doing all the drastic stuff people mentioned (reinstalling, rebuilding etc). So thanks for this.

The registry fix works and the CA2 launches fine. However ~5 minutes of working it crashes. I have even tried just leaving the application alone and do nothing, it eventually crashes around the same time. Although I havent time'd it to see if its the same amount of time.

So I decided to disable my wifi and it works fine without crashing! Although its usable, sometimes it a pain when i need the internet.

Is there another fix or update that may help?

Not sure if this helps
Problem signature:
  Problem Event Name:    APPCRASH
  Application Name:    CraftArtist.exe
  Application Version:    2.1.0.37
  Application Timestamp:    573b58ce
  Fault Module Name:    SerifCommon.dll
  Fault Module Version:    2.1.0.37
  Fault Module Timestamp:    573b545f
  Exception Code:    c0000005
  Exception Offset:    0000000000053d31
  OS Version:    6.1.7601.2.1.0.768.3
  Locale ID:    2057
  Additional Information 1:    6093
  Additional Information 2:    6093fab938747f72bbe3763d3f96ed30
  Additional Information 3:    5320
  Additional Information 4:    53206d4684056b60d8bedfbd17e348da